Open-LIFU

Open-LIFU 2.0

Open-LIFU is capable of probing diverse brain and body regions. The devices come ready to use out of the box, and the open source architecture allows for customization to suit a wide range of research needs. Standardized design features ensure that clinical studies conducted with these tools can generate critical data to inform the development of future portable, low-cost medical devices.

Key Features

Delivers low-intensity focused ultrasound (LIFU) therapy with precision and flexibility.

Patient-specific targeting; modular architecture
Lightweight, wearable, and portable for field use
Sophisticated software tools for planning, delivery, and monitoring
Flexible pulse parameters for tailored therapeutic protocols
Safety-focused design with IEC 60601-1 compliance
Complete system or OEM hardware/software components
Research use only; pre-FDA

How to Get One

Stunning tumor shrinkage was observed in a preclinical study of 38 mice with glioblastoma after a single 2-minute Openwater ultrasound treatment. Using our wearable, non-invasive headset—adapted for smaller mice—tumor growth dramatically decreased compared to controls.

_{Openwater. Results Overview: Preclinical Oncolysis Study Using Focused Ultrasound for Glioblastoma Lysis. White paper. Openwater, 2024.}

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BDI scores went from severe depression to remission in a week with 10 minutes per day therapy via Open-LIFU headgear device. Week 2 and 3 treatment see further improvements. Over 1/3 of patients reached remission in a 20 person clinical trial.

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Category	Parameter	Value
Sonication Parameters	Center frequencies Mechanical Index at focus Pulse length Duty Cycle Duration Focusing range (1 module) Focusing range (multi-module) Apodization Focal Patterns	100–500 kHz 0–1.9 MI 0–100 ms 0–50% 0–15 minutes 3 cm (150 kHz), 6 cm (400 kHz) 11 cm (deeper may be possible with more modules than 4×2 grid) Binary Single, Multi (rastered)
Transmit Modules	Number of Elements Transmit Electronics Center frequencies Footprint Communication Expansion ports Receive Channels	64 (8×8 grid) per single transducer On-module 150 kHz, 400 kHz 4×4 cm I2C, TTL I2C Expansion header
Transducers	Number of transmit modules Connection to console Affixation to body	Depending on frequency & duty cycle – Use of many transducers simultaneously at max power may require custom power supply – TBD Flexible Cable Multiple strap configurations
Console	Input Power Output Voltage Output Power Input Communication Port Size	120V / 240V AC +/- (5–96V) DC 60W Peak USB C 6” × 6” × 2”
Software	Operating System Memory Storage Connections GPU Simulation Engine Language Components	Windows 11 or later 8 GB of RAM 100 GB of free storage 1 available USB-C port (at least USB 3.0) NVIDIA Recommended K-Wave (python version) Python 1. Underlying Python Modules 2. Access controlled GUI
Transducer Tracking	Method Accuracy	3D Scanning TBD – requires < 2 mm
Compliance	IEC Standards ISO Standards	60601-1-1, 60601-1-2, 60601-1-6, 60601-2-5, 60601-2-37, 60601-2-62, 62304 13485, 10993

Open-LIFU

Open-LIFU 2.0

Key Features

Glioblastoma Study

Severe Depression Study

Specifications

Applications

Research

Technology

Community

Company