Open-LIFU:
(LOW-INTENSITY FOCUSED ULTRASOUND)

Openwater’s Low Intensity Focused Ultrasound (LIFU) platform for research.  The platform is flexible, easy-to-use, and can deliver LIFU to targets located nearly anywhere in the head or body. While Open-LIFU 2.0 devices are ready to set up “out of the box”, their open-source design allows customization and modification to support clinical research across diverse users and applications. At the same time, Open-LIFU 2.0’s controlled design features make it an effective solution for developing regulated medical devices that are portable and low-cost. By filling the gap between expensive research hardware available for proof-of-concept studies and commercially manufacturable hardware suitable for regulated medical devices, Open-LIFU 2.0 greatly facilitates the translation of novel therapies from bench to bedside.

Applications in:

Research Spotlight

Webinar: Transcranial Focused Ultrasound Neuromodulation of the Default Mode Network in the Treatment of Depression and Promotion of Wellness

Repetitive Negative Thinking (RNT)—including rumination and worry—is a transdiagnostic cognitive process central to major depressive disorder (MDD), generalized anxiety disorder (GAD), and obsessive-compulsive disorder (OCD). Elevated RNT is linked to increased connectivity within the brain’s Default Mode Network (DMN), which supports self-referential thought and is often hyperactive in these conditions.  Emerging evidence suggests that low-intensity transcranial focused ultrasound (litFUS) may reduce Repetitive Negative Thinking (RNT) and mood-related symptoms in clinical populations, and also promote emotional wellness in nonclinical groups.